Developing novel therapeutic interventions for the treatment malaria - Science/Technology - Nairaland
Nairaland Forum / Science/Technology / Developing novel therapeutic interventions for the treatment malaria (189 Views)
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| Developing novel therapeutic interventions for the treatment malaria by Clarendon: 6:20am On Dec 27, 2023 |
Malaria is a deadly disease that affects millions of people in Africa and around the world. According to the World Health Organization, over 200 million cases of malaria were recorded in Africa in the year 2022, accounting for 94% of worldwide cases. In another data, Nigeria is reported to have the highest number of malaria cases in Africa. This makes malaria a serious problem for us. Several therapeutic interventions have been developed for the treatment of malaria, but the disease still persists - killing people (mostly children) in numbers. I have created this thread to document ideas (largely scientific) that can be developed for the treatment and eradication of malaria in Africa - and the world at large. Feel free to share your ideas. On my part, I will study the topic extensively, and propose sustainable and long lasting therapeutic strategies for the treatment and eradication of malaria.
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| Re: Developing novel therapeutic interventions for the treatment malaria by Clarendon: 12:01am On Jan 03 |
Malaria is caused by the accumulation of certain protozoan parasites in the liver. Plasmodium falciparum is the most deadly of these parasites and is injected into the human body by female anopheles mosquitoes. While there are many types of parasites that cause malaria, P. falciparum is the most deadly. One way to eliminate this parasite is to inhibit the activity of integral enzymatic proteins in its metabolic pathway. Artemesinin, a small molecule, has been reported to be capable of inhibiting the activity of certain enzymes involved in P. falciparum’s metabolism. This is relatively well-studied. I will do some research to see many more small molecules capable of irreversibly binding to key proteins in P. falciparum’s metabolic pathways which are relevant for the growth and sustenance of the parasite. After the identification of such small molecules, I will strategically come up with ways in which such molecules can be produced, either via extraction from plant producers or via recombination engineering using biotechnological methods. Stay tuned as we develop therapeutic solutions for the complete treatment and ultimate eradication of malaria. |
| Re: Developing novel therapeutic interventions for the treatment malaria by Moshybear(f): 4:16pm On Jan 04 |
God bless your kind heart sir, quite educative. Happy new year  1 Like |
| Re: Developing novel therapeutic interventions for the treatment malaria by Clarendon: 2:27am On Jan 05 |
It seems we do not have so many people interested in biological sciences on this forum. |
| Re: Developing novel therapeutic interventions for the treatment malaria by Moshybear(f): 1:23pm On Jan 05 |
Clarendon:Well it depends on the value chain reaction. Most Nigerian citizens living in Nigeria are currently battling a hunger crisis caused by bad Governance, barely surviving each day that comes. Malaria is not their problem, hunger is, and I'm saying this with all sincerity. |
| Re: Developing novel therapeutic interventions for the treatment malaria by Clarendon: 5:36am On Jan 06 |
Moshybear: I fully understand that Maslow's heirachy of needs is currently fully at play in Nigeria, where the most pressing desires of the common man, is to meet primary physiological needs such as food, shelter and clothing. Only when such primary needs are met before one could begin to think about meeting secondary needs like social security and stability. While this is true, I still think these things are not mutually exclusive, and in a way, they intertwine. To earn money to buy food for instance, one way is to solve problems and charge people for solving their problems - "Cliche", you might say, but it is fact. Finding sustainable cure to malaria, trust me, is one way to hit a goldmine. The big phramas know this. |
| Re: Developing novel therapeutic interventions for the treatment malaria by Moshybear(f): 4:59pm On Jan 09 |
Clarendon:That's true, in my subconscious i fully know that some disease are "manufactured" mostly in labs so as to sell the healing medications and vaccines. The world is evil. Know this and know peace Jesus is still king  |
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